CRISPR/Cas9 technology has revolutionized modern biology, with gene editing now at the forefront of scientific research. At Creative Biogene, we specialize in delivering reliable and professional services aimed at advancing your research goals. Our chemically synthesized sgRNA products are meticulously designed for 100% sequence accuracy and efficient protein knockout capabilities. With added thiol and methoxy modifications at both ends, our sgRNA ensures enhanced stability and reduced off-target effects, providing scientists worldwide with trusted tools for successful gene editing experiments.

Advantages of Chemically Synthesized sgRNA

In vitro transcription and plasmid recombination expression are classic methods for producing sgRNA in the CRISPR-Cas9 gene editing system. However, these methods have practical limitations, including the time-consuming nature of synthesis and the difficulty in controlling the quality of sgRNA. Additionally, DNA or other contaminants may be introduced into cells. In contrast, chemically synthesized sgRNA offers several advantages. These factors make chemically synthesized sgRNA a more reliable choice for CRISPR editing. High-quality and controllable chemically synthesized sgRNA can optimize different CRISPR experimental conditions.